https://ihj.ideajournal.id/index.php/IHSE PT Mantaya Idea Batara en-US An Idea on Safety and Environment 3109-3590 https://ihj.ideajournal.id/index.php/IHSE/article/view/567 <p class="p1"><strong>Introduction: </strong>Pharmaceutical pollution has become a pressing global concern due</p> <p class="p1">to its role in the emergence of antimicrobial resistance in environmental settings.</p> <p class="p1"><strong>Objective:</strong> to synthesize current evidence on the link between pharmaceutical</p> <p class="p1">residues and resistance dissemination</p> <p class="p1"><strong>Method:</strong> A systematic literature review was conducted using PubMed, Scopus,</p> <p class="p1">Web of Science, ScienceDirect, and Google Scholar. From an initial pool of</p> <p class="p1">records, ten empirical articles were included. Inclusion criteria required that studies</p> <p class="p1">examined pharmaceutical residues in environmental matrices and reported</p> <p class="p1">associations with antimicrobial resistance genes, were peer-reviewed, and written</p> <p class="p1">in English. Exclusion criteria eliminated reviews, commentaries, conference</p> <p class="p1">abstracts without full text, and studies limited to clinical settings. The reviewed</p> <p class="p1">articles encompassed field investigations, laboratory analyses, and policy</p> <p class="p1">evaluations.</p> <p class="p1"><strong>Result:</strong> indings revealed that pharmaceutical residues, especially antibiotics such</p> <p class="p1">as fluoroquinolones and sulfonamides, persist in surface waters, sediments, and</p> <p class="p1">soils, exerting continuous selective pressures that foster resistance gene</p> <p class="p1">development. Mobile genetic elements facilitated rapid dissemination of</p> <p class="p1">antimicrobial resistance among microbial populations. Geographic disparities were</p> <p class="p1">evident, with low- and middle-income countries facing disproportionately higher</p> <p class="p1">contamination levels due to weak infrastructure and limited regulation. Mitigation</p> <p class="p1">strategies, including advanced wastewater treatment, constructed wetlands,</p> <p class="p1">medicine take-back programs, and awareness campaigns, showed promise but</p> <p class="p1">were constrained by cost and fragmented implementation. These findings highlight</p> <p class="p1">the urgent need for integrated, One Health approaches to reduce pharmaceutical</p> <p class="p1">pollution and address its contribution to antimicrobial resistance. By consolidating</p> <p class="p1">evidence and identifying gaps,</p> <p class="p1"><strong>Conclusion:</strong> his review enhances understanding of the environmental dimension</p> <p class="p1">of resistance and informs future research and policy interventions.</p> Hafsah Hafsah Copyright (c) 2025 An Idea on Safety and Environment https://creativecommons.org/licenses/by/4.0/ 2025-10-01 2025-10-01 1 02 25 38 10.53690/ise.v1i02.567 https://ihj.ideajournal.id/index.php/IHSE/article/view/577 <p>Introduction: Heavy equipment operators are prone to incidents, particularly due to fatigue, which affects concentration and safety. Although companies have committed to safety measures, incidents still occur due to various internal and external factors. Objective: This study aims to analyze the factors influencing workplace accidents among heavy equipment operators. Method: The research method used a quantitative research design with a crosssectional approach, with a sample of 99 heavy equipment operators selected using simple random sampling. Data analysis was performed using the Chisquare test and Logistic Regression Test. Result: The results of the study indicate that work fatigue has a significant effect on workplace accidents (p = 0.048 &lt; 0.05), age also has a significant effect on workplace accidents (p = 0.025 &lt; 0.05), Nutritional status does not show a significant relationship with workplace accidents (p = 0.111 &gt; 0.05), Workload is proven to have a significant effect (p = 0.008 &lt; 0.05), and length of service is also significantly associated with workplace accidents (p = 0.048 &lt; 0.05). Conclusion: The conclusion of this study is that there is a significant relationship between work fatigue, age, workload, and length of service with work accidents at PT. Subur Sedaya Maju. There is no relationship between nutritional status and work accidents at PT. Subur Sedaya Maju. Therefore, the company should consider adding work shifts to improve operational efficiency and reduce the workload on existing shifts, as well as conduct a comprehensive and ongoing evaluation of factors that may contribute to workplace accidents</p> Dinda Rahma Revalita Dina Waldani Poppy Fujianti Copyright (c) 2025 An Idea on Safety and Environment https://creativecommons.org/licenses/by/4.0/ 2025-10-29 2025-10-29 1 02 39 49 10.53690/ise.v1i02.577